Company Overview
- Headquarters
- 2545 Golden Bear Drive, Suite 110, Carrollton TX
- Website
- gradalisinc.com
- Phone
- (214) 442-8100
- Employees
- 48
- Founded in
- 2003
- Industry
- BioTech/Drugs
Financials & Stats
Revenue
$10B
Who is Gradalis
Gradalis is a late-stage clinical biotechnology company headquartered in Carrollton, Texas. The company employs 48 individuals. Gradalis develops immunotherapies for various cancer indications, focusing on a proprietary bi-shRNA therapy platform. This platform has demonstrated effectiveness in silencing a wide range of genes and holds potential applications for multiple cancer types. Their flagship product, Vigil, is a cellular therapy designed to enhance the immune system's ability to recognize and attack cancer cells. Vigil utilizes a patient's tumor-related antigens for targeted identification and employs a three-pronged approach: blocking immunosuppressive cytokines, activating effector immune cells, and inducing an immune response to tumor neo-antigens. Vigil has shown promising results in clinical trials, particularly in patients with ovarian cancer. Phase 2b trials demonstrated a positive trend in recurrence-free survival and significant improvements in recurrence-free survival and overall survival in a subgroup of BRCA wild-type ovarian cancer patients. Gradalis is preparing to initiate a registration trial for Vigil in this patient population. Additionally, Phase 1 trials in a broader patient cohort have revealed positive signals of activity across multiple tumor types. For more information, please visit gradalisinc.com.
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